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gliotoxin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
3-benzyl-3,6_-dithio-6-(hydroxymethyl)-diketopiperazine + O2 <=> 3-benzyl-3,6_-disulfide-6-(hydroxymethyl)-diketopiperazine + H2O2 1.8.3.2 thiol oxidase

S-adenosyl-L-methionine + N-desmethyl-gliotoxin <=> gliotoxin + S-adenosyl-L-homocysteine + H+ 2.1.1

3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + glutathione <=> 3-benzyl-3,6_-bis(glutathione)-_6-(hydroxymethyl)-diketopiperazine + H2O 2.5.1.18 glutathione transferase

3-benzyl-3,6_-bis(cysteinyl)-_6-(hydroxymethyl)-diketopiperazine + H2O <=> 3-benzyl-3,6_-dithio-6-(hydroxymethyl)-diketopiperazine + NH3 + pyruvate 4.4.1

cyclo(L-phenylalanyl-L-seryl) + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + oxidized_[NADPH-hemoprotein_reductase] + H2O 1.14.14

L-phenylalanine + L-serine + ATP <=> cyclo(L-phenylalanyl-L-seryl) + ADP + phosphate + H+ 6.3.2

3-benzyl-3,6_-bis(cysteinylglycine)-_6-(hydroxymethyl)-diketopiperazine + H2O <=> 3-benzyl-3,6_-bis(cysteinyl)-_6-(hydroxymethyl)-diketopiperazine + glycine 3.4.13.19 membrane dipeptidase

3-benzyl-3,6_-disulfide-6-(hydroxymethyl)-diketopiperazine <=> N-desmethyl-gliotoxin not assigned

3-benzyl-3,6_-bis(glutathione)-_6-(hydroxymethyl)-diketopiperazine <=> 3-benzyl-3,6_-bis(cysteinylglycine)-_6-(hydroxymethyl)-diketopiperazine + 5-oxoproline 4.3.2

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